Serum Cystatin-C as a Marker of Acute Kidney Injury in the Newborn After Perinatal Hypoxia/Asphyxia

We evaluated cystatin‐C (cysC) in the umbilical blood as a predictor of acute kidney injury (AKI) after perinatal hypoxia/asphyxia compared with creatinine (Cr). One hundred full‐term newborns were enrolled in the study (50 in a group affected by perinatal hypoxia/asphyxia [AS] and 50 controls). Cys...

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Veröffentlicht in:Therapeutic apheresis and dialysis 2014-02, Vol.18 (1), p.57-67
Hauptverfasser: Treiber, Milena, Gorenjak, Maksimiljan, Pecovnik Balon, Breda
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Sprache:eng
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Zusammenfassung:We evaluated cystatin‐C (cysC) in the umbilical blood as a predictor of acute kidney injury (AKI) after perinatal hypoxia/asphyxia compared with creatinine (Cr). One hundred full‐term newborns were enrolled in the study (50 in a group affected by perinatal hypoxia/asphyxia [AS] and 50 controls). CysC and Cr were measured in blood samples from the umbilical cord at birth (cysC‐umb and Cr‐umb) and from a peripheral vein 3 days later (cysC‐3 and Cr‐3). At birth, the mean level of cysC in healthy term babies was found to be 1.39 ± 0.19 mg/L and 1.34 ± 0.21 mg/L after 3 days of life, not significantly decreased (P = 0.137). The mean of cysC in the AS group was 2.12 ± 0.53 mg/L in cord blood and 1.56 ± 0.32 g/L in day 3 blood samples, also decreased (P 
ISSN:1744-9979
1744-9987
DOI:10.1111/1744-9987.12054