Evidence that monoclonal antibody production kinetics is related to the integral of the viable cells curve in Batch systems

Monoclonal antibody production kinetics in batch systems is linearly related to the integral of the viable cells curve. This favors the secretion theory over that of release by dead cells. Regression of the production curve over the integral of the viable cells curve in different media can also give...

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Veröffentlicht in:	Biotechnology letters 1988-02, Vol.10 (2), p.91-96
Hauptverfasser:	RENARD, J. M, SPAGNOLI, R, MAZIER, C, SALLES, M. F, MANDINE, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biotechnology Fundamental and applied biological sciences. Psychology Health. Pharmaceutical industry hybridoma Industrial applications and implications. Economical aspects Miscellaneous Monoclonal antibodies Production of active biomolecules
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Zusammenfassung:	Monoclonal antibody production kinetics in batch systems is linearly related to the integral of the viable cells curve. This favors the secretion theory over that of release by dead cells. Regression of the production curve over the integral of the viable cells curve in different media can also give information on the nutritional requirements of the cells for growth and production.
ISSN:	0141-5492 1573-6776
DOI:	10.1007/BF01024632