Effect of pretreatment with hepatic microsomal enzyme inducers on the toxicity of diazinon in calves

The pretreatment of calves with a single dose of 10 mg kg−1 dieldrin or 21 daily doses of 10 mg kg−1 phenobarbitone increased the toxicity of diazinon as reflected by the development of more severe clinical signs and greater depression in whole blood cholinesterase activity in the pretreated calves....

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Veröffentlicht in:Research in veterinary science 1986-11, Vol.41 (3), p.336-339
Hauptverfasser: ABDELSALAM, E.B., FORD, E.J.H.
Format: Artikel
Sprache:eng
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Zusammenfassung:The pretreatment of calves with a single dose of 10 mg kg−1 dieldrin or 21 daily doses of 10 mg kg−1 phenobarbitone increased the toxicity of diazinon as reflected by the development of more severe clinical signs and greater depression in whole blood cholinesterase activity in the pretreated calves. Induction by dieldrin or phenobarbitone of the hepatic microsomal enzyme amidopyrine-N-demethylase was also accompanied by a concurrent rise in the liver carboxyl-esterase activity.
ISSN:0034-5288
1532-2661
DOI:10.1016/S0034-5288(18)30626-X