Irreversible inhibition of the TXA sub(2)/PGH sub(2) receptor of human platelets by photoaffinity ligand

Irreversible inhibition of the TXA sub(2)/PGH sub(2) receptor of human platelets by photoaffinity ligand

In order of tag the TXA sub(2)/PGH sub(2) receptor of human platelets, the authors synthesized azido-BSP (= 4-(2-(4-azido-benzenesulfonylamino)-ethyl)phenoxyacetic acid), a photolabile derivative of the specific TXA sub(2)/PGH sub(2) receptor antagonist sulotroban. The results show that azido-BSP is...

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Veröffentlicht in:Biochemical pharmacology 1988-01, Vol.37 (3), p.491-495
Hauptverfasser: Zehender, H, Witte, E C, Wolff, H P, Patscheke, H
Format: Artikel
Sprache:eng
Schlagworte:
man
platelets
prostaglandin H2
thromboxane A2
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Zusammenfassung:In order of tag the TXA sub(2)/PGH sub(2) receptor of human platelets, the authors synthesized azido-BSP (= 4-(2-(4-azido-benzenesulfonylamino)-ethyl)phenoxyacetic acid), a photolabile derivative of the specific TXA sub(2)/PGH sub(2) receptor antagonist sulotroban. The results show that azido-BSP is a specific and high affinity ligand of the TXA sub(2)/PGH sub(2) receptor and that it covalently links to the receptor under irradiation. Azido-BSP is a new tool to identify and characterize the TXA sub(2)/PGH sub(2) receptor.
ISSN:0006-2952