Raltegravir pharmacokinetics in HIV/HCV-coinfected patients with advanced liver cirrhosis (Child-Pugh C)

Raltegravir pharmacokinetics in HIV/HCV-coinfected patients with advanced liver cirrhosis (Child-Pugh C)

To describe raltegravir pharmacokinetics at steady-state in HIV/hepatitis C virus (HCV)-coinfected patients under antiretroviral (ARV) treatment with (n = 5) and without (n = 5) advanced liver cirrhosis (Child-Pugh C). This was a non-randomized, Phase I, parallel-assignment, open-label pharmacokinet...

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Veröffentlicht in:Journal of antimicrobial chemotherapy 2014-02, Vol.69 (2), p.471-475
Hauptverfasser: Hernández-Novoa, Beatriz, Moreno, Ana, Pérez-Elías, María J, Quereda, Carmen, Dronda, Fernando, Casado, José L, Madrid-Elena, Nadia, Aguilar, Mónica, Fumero, Emilio, Moltó, José, Moreno, Santiago
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Antiretroviral drugs
Female
Hepatitis
Hepatitis C - blood
Hepatitis C - drug therapy
Hepatitis C - epidemiology
Hepatitis C virus
HIV
HIV Infections - blood
HIV Infections - drug therapy
HIV Infections - epidemiology
HIV Integrase Inhibitors - blood
HIV Integrase Inhibitors - pharmacokinetics
HIV Integrase Inhibitors - therapeutic use
Human immunodeficiency virus
Humans
Liver cirrhosis
Liver Cirrhosis - blood
Liver Cirrhosis - drug therapy
Liver Cirrhosis - epidemiology
Male
Middle Aged
Protease inhibitors
Pyrrolidinones - blood
Pyrrolidinones - pharmacokinetics
Pyrrolidinones - therapeutic use
Raltegravir Potassium
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Zusammenfassung:To describe raltegravir pharmacokinetics at steady-state in HIV/hepatitis C virus (HCV)-coinfected patients under antiretroviral (ARV) treatment with (n = 5) and without (n = 5) advanced liver cirrhosis (Child-Pugh C). This was a non-randomized, Phase I, parallel-assignment, open-label pharmacokinetic study in HIV/HCV-coinfected patients with Child-Pugh grade C hepatic cirrhosis. We recruited clinically stable HIV/HCV-coinfected adult patients with controlled HIV viraemia (
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/dkt386