A redox-responsive cationic supramolecular polymer constructed from small molecules as a promising gene vector

A redox-responsive cationic supramolecular polymer constructed from small molecules as a promising gene vector

A novel class of redox-responsive cationic supramolecular polymer with effective DNA condensation ability and H2O2-induced DNA release behavior has been successfully constructed from small molecules. This supramolecular polymer can be used in vitro as a promising nonviral vector for gene therapy.

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Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2013-10, Vol.49 (84), p.9845-9847
Hauptverfasser: Dong, Ruijiao, Su, Yue, Yu, Songrui, Zhou, Yongfeng, Lu, Yunfeng, Zhu, Xinyuan
Format: Artikel
Sprache:eng
Schlagworte:
beta-Cyclodextrins - chemistry
Cations - chemistry
Chemical communication
Dimerization
DNA - chemistry
Ferrous Compounds - chemistry
Genetic Therapy
Genetic Vectors - chemistry
Hydrogen Peroxide - chemistry
Macromolecular Substances - chemistry
Metallocenes
Oxidation-Reduction
Plasmids - chemistry
Polymers - chemistry
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Beschreibung
Zusammenfassung:A novel class of redox-responsive cationic supramolecular polymer with effective DNA condensation ability and H2O2-induced DNA release behavior has been successfully constructed from small molecules. This supramolecular polymer can be used in vitro as a promising nonviral vector for gene therapy.
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc46123h