Mechanochemical Properties of Individual Human Telomeric RNA (TERRA) G-Quadruplexes

Mechanochemical Properties of Individual Human Telomeric RNA (TERRA) G-Quadruplexes

Potential functions: By following the unfolding and refolding of individual human RNA telomeric (TERRA) G‐quadruplexes (GQs) in laser tweezers, the mechanical stability and transition kinetics of RNA GQs are obtained. Comparison between TERRA and DNA GQs suggests their different regulatory capacitie...

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Veröffentlicht in:Chembiochem : a European journal of chemical biology 2013-10, Vol.14 (15), p.1931-1935
Hauptverfasser: Yangyuoru, Philip M., Zhang, Amy Y. Q., Shi, Zhe, Koirala, Deepak, Balasubramanian, Shankar, Mao, Hanbin
Format: Artikel
Sprache:eng
Schlagworte:
Base Sequence
G-Quadruplexes
Humans
laser tweezers
Mechanical Phenomena
mechanical stability
mechanochemistry
Models, Molecular
RNA - chemistry
RNA - genetics
RNA structures
single molecules
Telomere - genetics
TERRA
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Beschreibung
Zusammenfassung:Potential functions: By following the unfolding and refolding of individual human RNA telomeric (TERRA) G‐quadruplexes (GQs) in laser tweezers, the mechanical stability and transition kinetics of RNA GQs are obtained. Comparison between TERRA and DNA GQs suggests their different regulatory capacities for processes associated with human telomeres.
ISSN:1439-4227
1439-7633
DOI:10.1002/cbic.201300350