DNA Methylation of IGF2DMR and H19 Is Associated with Fetal and Infant Growth: The Generation R Study: e81731

DNA Methylation of IGF2DMR and H19 Is Associated with Fetal and Infant Growth: The Generation R Study: e81731

Changes in epigenetic programming of embryonic growth genes during pregnancy seem to affect fetal growth. Therefore, in a population-based prospective birth cohort in the Netherlands, we examined associations between fetal and infant growth and DNA methylation of IGF2DMR, H19 and MTHFR. For this stu...

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Veröffentlicht in:PloS one 2013-12, Vol.8 (12)
Hauptverfasser: Bouwland-Both, Marieke I, Mil, Nina Hvan, Stolk, Lisette, Eilers, Paul HC, Verbiest, M PJ, Heijmans, Bastiaan T, Tiemeier, Henning, Hofman, Albert, Steegers, Eric AP, Jaddoe, Vincent WV
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Sprache:eng
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Zusammenfassung:Changes in epigenetic programming of embryonic growth genes during pregnancy seem to affect fetal growth. Therefore, in a population-based prospective birth cohort in the Netherlands, we examined associations between fetal and infant growth and DNA methylation of IGF2DMR, H19 and MTHFR. For this study, we selected 69 case children born small-for-gestational age (SGA, birth weight
ISSN:1932-6203
DOI:10.1371/journal.pone.0081731