The complete amino acid sequence of rat beta sub(2)-microglobulin

The primary structure of rat beta sub(2)-microglobulin ( beta sub(2)m) was determined. It is a polypeptide of 99 amino acids. The primary structure was determined by NH sub(2)-terminal sequence analysis together with sequence determination of one cyanogen bromide fragment and one tryptic peptide. Of other known beta sub(2)m sequences, rat beta sub(2)m is most homologous to mouse beta sub(2)m (83% identity). The rabbit, human, and guinea pig sequences are more distant, with 24, 27, and 31% differences, respectively.