Two-day cefamandole versus five-day cephazolin prophylaxis in 965 total hip replacements: Report of a multicentre double randomised trial

The aim of this trial was to compare a 5-day course of cephazolin with a regimen of 2 days of cefamandole in 965 total hip replacements. The effect of the prophylactic antibiotic on the bacterial colonization of drains (mean duration of drainage: 3.2 plus or minus 0.3 days) and on the susceptibility of colonizing organisms was assessed. No significant difference was observed in the percentage of infected drains between the two groups. The cefamandole group had a lower rate of Gram-negative organisms (23% versus 44%). The rate of deep infections within one year after operation was 0.7% in the cefamandole group versus 0.5% in the cephazolin group, and the difference is not significant.