The Sulfonamide Motif as a Synthetic Tool

Sulfonamides are well known motifs in medicinal chemistry, forming a large family of antibacterial agents as well as being found in numerous other drugs. The chemistry of this functional group, however, is less well documented. This review seeks to bring together the various applications and advanta...

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Veröffentlicht in:Journal of chemical research 2010-10, Vol.34 (10), p.541-548
1. Verfasser: Wilden, Jonathan D
Format: Artikel
Sprache:eng
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Zusammenfassung:Sulfonamides are well known motifs in medicinal chemistry, forming a large family of antibacterial agents as well as being found in numerous other drugs. The chemistry of this functional group, however, is less well documented. This review seeks to bring together the various applications and advantages of this motif in organic synthesis, which includes the sulfonamide as an activating group, protecting group, leaving group and as a molecular scaffold.
ISSN:1747-5198
2047-6507
DOI:10.3184/030823410X12857514635822