Synthesis of (1R,2S)-2-(4′-Allyl-2′,6′-Dimethoxyphenoxyl)-1-(4″-Hydroxy-3″, 5″-Dimethoxyphenyl)Propan-1-ol

Synthesis of (1R,2S)-2-(4′-Allyl-2′,6′-Dimethoxyphenoxyl)-1-(4″-Hydroxy-3″, 5″-Dimethoxyphenyl)Propan-1-ol

The asymmetric synthesis of the natural neolignan (1R,2S)-2-(4′-allyl-2′,6′-dimethoxyphenoxyl)-1-(4″-hydroxy-3″,5″-dimethoxyphenyl)propan-1-ol based on an asymmetric dihydroxylation as a key reaction using AD-mix-β to preparing the chiral threo-(1R,2R)-glycerol. The reaction, threo-alcohols were inv...

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Veröffentlicht in:Journal of chemical research 2011-09, Vol.35 (9), p.519-521
Hauptverfasser: Ding, Junwei, Qi, Rongwei, Zhou, Haitang, Jiao, Bin, Xia, Yamu
Format: Artikel
Sprache:eng
Schlagworte:
Asymmetry
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Zusammenfassung:The asymmetric synthesis of the natural neolignan (1R,2S)-2-(4′-allyl-2′,6′-dimethoxyphenoxyl)-1-(4″-hydroxy-3″,5″-dimethoxyphenyl)propan-1-ol based on an asymmetric dihydroxylation as a key reaction using AD-mix-β to preparing the chiral threo-(1R,2R)-glycerol. The reaction, threo-alcohols were inverted by an S N 2 reaction into erythro-(1R,2S)-isomers.
ISSN:1747-5198
2047-6507
DOI:10.3184/174751911X13149759277234