High coating of Ru(II) complexes on gold nanoparticles for single particle luminescence imaging in cells

Gold nanoparticles are efficiently labelled with a luminescent ruthenium complex, producing 13 and 100 nm diameter, monodisperse red-emissive imaging probes with luminescence lifetimes prolonged over the molecular unit. Single, 100 nm particles are observed in whole cell luminescence imaging which r...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2014-01, Vol.50 (5), p.617-619
Hauptverfasser:	Rogers, Nicola J, Claire, Sunil, Harris, Robert M, Farabi, Shiva, Zikeli, Gerald, Styles, Iain B, Hodges, Nikolas J, Pikramenou, Zoe
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Cell Line, Tumor Coordination Complexes - chemical synthesis Coordination Complexes - chemistry Coordination Complexes - metabolism Gold - chemistry Humans Metal Nanoparticles - chemistry Microscopy, Confocal Particle Size Ruthenium - chemistry
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Beschreibung
Zusammenfassung:	Gold nanoparticles are efficiently labelled with a luminescent ruthenium complex, producing 13 and 100 nm diameter, monodisperse red-emissive imaging probes with luminescence lifetimes prolonged over the molecular unit. Single, 100 nm particles are observed in whole cell luminescence imaging which reveals their biomolecular association with chromatin in the nucleus of cancer cells.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c3cc47606e