Non-Enzymatic Geometry-Selective Acylation of Tri- and Tetrasubstituted [alpha],[alpha]'-Alkenediols

Non-Enzymatic Geometry-Selective Acylation of Tri- and Tetrasubstituted [alpha],[alpha]'-Alkenediols

A highly geometry-selective organocatalytic acylation of tri- and tetra-substituted 2-alkylidene-1,3-propanediols has been developed. The highly E-selective acylation of various tetrasubstituted 2-alkylidene-1,3-propanediols was achieved in 96 to >99% selectivity for the first time by a non-enzym...

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Veröffentlicht in:Advanced synthesis & catalysis 2012-11, Vol.354 (17), p.3291-3298
Hauptverfasser: Yoshida, Keisuke, Mishiro, Kenji, Ueda, Yoshihiro, Shigeta, Takashi, Furuta, Takumi, Kawabata, Takeo
Format: Artikel
Sprache:eng
Schlagworte:
Acylation
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Zusammenfassung:A highly geometry-selective organocatalytic acylation of tri- and tetra-substituted 2-alkylidene-1,3-propanediols has been developed. The highly E-selective acylation of various tetrasubstituted 2-alkylidene-1,3-propanediols was achieved in 96 to >99% selectivity for the first time by a non-enzymatic protocol.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201200242