Copper-Catalyzed Activation of Dioxygen: Oxidative Cyclization of 2-Arylindoles

A series of unusual six‐ring‐fused heterocycles containing indole and quinoline skeletons was successfully synthesized by a copper‐catalyzed reaction from 2‐arylated indoles. Two new bonds were regioselectively formed from CH and CH coupling. 18O‐Labelled experiments revealed that the dioxygen is...

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Veröffentlicht in:	Advanced synthesis & catalysis 2012-07, Vol.354 (10), p.1873-1878
Hauptverfasser:	Sang, Peng, Xie, Yongju, Zou, Jianwei, Zhang, Yuhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Catalysis Chemistry copper Exact sciences and technology heterocycles Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives Indoles Joining Labelled compounds chemistry Organic chemistry Oxidants oxidative cyclization Oxidizing agents oxygen Preparations and properties Quinoline Reactivity and mechanisms Synthesis
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Beschreibung
Zusammenfassung:	A series of unusual six‐ring‐fused heterocycles containing indole and quinoline skeletons was successfully synthesized by a copper‐catalyzed reaction from 2‐arylated indoles. Two new bonds were regioselectively formed from CH and CH coupling. 18O‐Labelled experiments revealed that the dioxygen is not only the oxidant but also the reactant.
ISSN:	1615-4150 1615-4169
DOI:	10.1002/adsc.201200162