One pot synthesis of bioactive benzopyranones through palladium-catalyzed C-H activation and CO insertion into 2-arylphenols

One pot synthesis of bioactive benzopyranones through palladium-catalyzed C-H activation and CO insertion into 2-arylphenols

Palladium-catalyzed oxidative carbonylation of 2-arylphenols through C-H bond activation and C-C and C-O bond formation under acid-base free and mild conditions has been developed. The reaction tolerates a variety of substrates and provides biologically important benzopyranone derivatives in up to 8...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2013-12, Vol.49 (100), p.11797-11799
Hauptverfasser: Lee, Tai-Hua, Jayakumar, Jayachandran, Cheng, Chien-Hong, Chuang, Shih-Ching
Format: Artikel
Sprache:eng
Schlagworte:
Activation
Benzopyrans - chemical synthesis
Benzopyrans - chemistry
Carbon Monoxide - chemistry
Catalysis
Molecular Structure
Palladium - chemistry
Phenol - chemistry
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Zusammenfassung:Palladium-catalyzed oxidative carbonylation of 2-arylphenols through C-H bond activation and C-C and C-O bond formation under acid-base free and mild conditions has been developed. The reaction tolerates a variety of substrates and provides biologically important benzopyranone derivatives in up to 87% isolated yield.
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc47197g