Asymmetric [alpha]-Amination of Aldehydes by a Recyclable Resin-Supported Peptide Catalyst

Asymmetric [alpha]-Amination of Aldehydes by a Recyclable Resin-Supported Peptide Catalyst

The asymmetric [alpha]-amination of aldehydes was performed using a resin-supported peptide catalyst. A tri- or tetrapeptide with an N-terminal D-Pro-Aib sequence efficiently catalyzed the reaction in a highly enantioselective manner. The supported catalyst could be easily recovered by filtration an...

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Veröffentlicht in:Advanced synthesis & catalysis 2013-02, Vol.355 (2-3), p.294-296
Hauptverfasser: Tanaka, Tatsuyoshi, Akagawa, Kengo, Mitsuda, Masaru, Kudo, Kazuaki
Format: Artikel
Sprache:eng
Schlagworte:
Aldehydes
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Zusammenfassung:The asymmetric [alpha]-amination of aldehydes was performed using a resin-supported peptide catalyst. A tri- or tetrapeptide with an N-terminal D-Pro-Aib sequence efficiently catalyzed the reaction in a highly enantioselective manner. The supported catalyst could be easily recovered by filtration and reused at least ten times.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201200611