Palladium-Catalyzed Direct Denitrogenative C-3-Arylation of 1H-Indoles with Arylhydrazines using Air as the Oxidant

Palladium-Catalyzed Direct Denitrogenative C-3-Arylation of 1H-Indoles with Arylhydrazines using Air as the Oxidant

A novel palladium‐catalyzed approach to direct C‐3‐arylation of 1H‐indoles with arylhydrazines using air as the oxidant via CN bond cleavage has been developed. Various substituents are tolerated in this system in moderate to good yields. This reaction could also be compatible with a larger scale....

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Veröffentlicht in:Advanced synthesis & catalysis 2013-03, Vol.355 (4), p.711-715
Hauptverfasser: Chen, Yongxin, Guo, Shuaibo, Li, Kangning, Qu, Jinpeng, Yuan, Hua, Hua, Qiuru, Chen, Baohua
Format: Artikel
Sprache:eng
Schlagworte:
3-aryl-1H-indoles
arylhydrazines
Bonding
Cleavage
Compatibility
CH activation
denitrogenative process
Oxidants
Oxidizing agents
palladium-catalyzed reaction
Strategy
Synthesis
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Beschreibung
Zusammenfassung:A novel palladium‐catalyzed approach to direct C‐3‐arylation of 1H‐indoles with arylhydrazines using air as the oxidant via CN bond cleavage has been developed. Various substituents are tolerated in this system in moderate to good yields. This reaction could also be compatible with a larger scale. Thus, this strategy using arylhydrazines as arylating reagents provides a powerful method for constructing substituted 3‐aryl‐1H‐indoles.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201200997