A Continuous Flow Solution to Achieving Efficient Aerobic Anti-Markovnikov Wacker Oxidation

An aerobic anti‐Markovnikov Wacker oxidation for the flow‐synthesis of arylacetaldehydes is reported. In the process, flow chemistry techniques have provided a means to control and minimise the over‐oxidation of sensitive products. The reaction showed general applicability to various functionalised...

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Veröffentlicht in:	Advanced synthesis & catalysis 2013-07, Vol.355 (10), p.1905-1910
Hauptverfasser:	Bourne, S. L., Ley, S. V.
Format:	Artikel
Sprache:	eng
Schlagworte:	aerobic Wacker oxidation Catalysis gas-liquid flow microreactors palladium catalysis tube-in-tube
Online-Zugang:	Volltext
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Zusammenfassung:	An aerobic anti‐Markovnikov Wacker oxidation for the flow‐synthesis of arylacetaldehydes is reported. In the process, flow chemistry techniques have provided a means to control and minimise the over‐oxidation of sensitive products. The reaction showed general applicability to various functionalised styrenes and provided a process capable of a multi‐gram scale.
ISSN:	1615-4150 1615-4169
DOI:	10.1002/adsc.201300278