A Facile One Step Synthesis of 3-(2-oxo-2H-chromen-3-yl)-indeno-[2,1-c]pyridazin-9-one

3-Acetylcoumarins (1) on reaction with ninhydrin (2) in acetic acid followed by treatment of in situ formed 2-hydroxy-2-[2-oxo-2-(2-oxo-2H-chromen-3-yl)-ethyl]indan-1,3-diones (3) with hydrazine hydrate resulted in the formation of corresponding 3-(2-oxo-2H-chromen-3-yl)-indeno[2,1-c]pyridazin-9-one...

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Veröffentlicht in:Journal of chemical research 2005-04, Vol.2005 (4), p.267-269
Hauptverfasser: Rao, V Rajeswar, Kumar, P Vijaya
Format: Artikel
Sprache:eng
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Zusammenfassung:3-Acetylcoumarins (1) on reaction with ninhydrin (2) in acetic acid followed by treatment of in situ formed 2-hydroxy-2-[2-oxo-2-(2-oxo-2H-chromen-3-yl)-ethyl]indan-1,3-diones (3) with hydrazine hydrate resulted in the formation of corresponding 3-(2-oxo-2H-chromen-3-yl)-indeno[2,1-c]pyridazin-9-ones (4) in a single step with an excellent yields. The structures of newly synthesised compounds (4) were confirmed by unambiguous synthesis involving a two step process from 3-acetylcoumarins.
ISSN:1747-5198
2047-6507
DOI:10.3184/0308234054213447