Microwave-promoted synthesis of ?-hydroxyesters by the Reformatsky reaction in the absence of solvent

A microwave-promoted Reformatsky reaction of aldehydes and ketones with ethyl bromoacetate, in the absence of solvent, using activated zinc metal and solid NH4Cl afforded the corresponding ?-hydroxyesters in good to excellent yields.

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Veröffentlicht in:Journal of chemical research 2003-06, Vol.2003 (6), p.374-376
Hauptverfasser: Gholap, Atul R, Chavan, Abhijit P
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container_title Journal of chemical research
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creator Gholap, Atul R
Chavan, Abhijit P
description A microwave-promoted Reformatsky reaction of aldehydes and ketones with ethyl bromoacetate, in the absence of solvent, using activated zinc metal and solid NH4Cl afforded the corresponding ?-hydroxyesters in good to excellent yields.
doi_str_mv 10.3184/030823403103174209
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title Microwave-promoted synthesis of ?-hydroxyesters by the Reformatsky reaction in the absence of solvent
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