The synthesis of deuterium labeled T-2 toxin

The synthesis of deuterium labeled T-2 toxin

We report the synthesis of isotopically pure trideuteriated T‐2 toxin, a useful internal standard for mycotoxin analysis. Peracetylation of HT‐2 toxin with hexadeuteriated acetic anhydride, followed by selective hydrolysis of the C‐3 acetate afforded the desired compound in good yield.

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Veröffentlicht in:Journal of labelled compounds & radiopharmaceuticals 1988-03, Vol.25 (3), p.345-348
Hauptverfasser: Michaud, Dennis P., Karger, B. L., Vouros, Paul
Format: Artikel
Sprache:eng
Schlagworte:
deuterium
mass spectrometry
mycotoxin
T-2 toxin
trichothecene
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Zusammenfassung:We report the synthesis of isotopically pure trideuteriated T‐2 toxin, a useful internal standard for mycotoxin analysis. Peracetylation of HT‐2 toxin with hexadeuteriated acetic anhydride, followed by selective hydrolysis of the C‐3 acetate afforded the desired compound in good yield.
ISSN:0362-4803
1099-1344
DOI:10.1002/jlcr.2580250314