Evolution of the subsolid pulmonary nodule: a retrospective study in patients with different neoplastic diseases in a nonscreening clinical context

Purpose The aims of this study were to evaluate the high-resolution computed tomography (HRCT) features of subsolid pulmonary nodules (SSN) detected in cancer patients to differentiate between benign and malignant lesions, to assess their evolution during the follow-up, and to determine which neopla...

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Veröffentlicht in:Radiologia medica 2013-12, Vol.118 (8), p.1269-1280
Hauptverfasser: Attinà, Domenico, Niro, Fabio, Stellino, Margherita, Ciccarese, Federica, Mineo, Giangaspare, Sverzellati, Nicola, Zompatori, Maurizio
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Sprache:eng
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Zusammenfassung:Purpose The aims of this study were to evaluate the high-resolution computed tomography (HRCT) features of subsolid pulmonary nodules (SSN) detected in cancer patients to differentiate between benign and malignant lesions, to assess their evolution during the follow-up, and to determine which neoplastic diseases are most frequently associated with the growth in size and/or density of SSN. Materials and methods Ninety-seven patients with a total of 146 subsolid nodules [140 pure ground-glass opacities (pGGOs) and six mixed ground-glass opacities (mGGOs)] were retrospectively recruited. Two chest radiologists independently reviewed the HRCT features of the nodules (location, shape, size, density) and the patients’ clinical characteristics (sex, age, smoking and cancer history). Mean duration of follow-up was more than 2 years. Results During follow-up, 58% of SSN remained stable, 10% disappeared. An increase in size and/or density was seen in 32% of SSN, and in particular in partly solid (mGGOs), large (≥10 mm) and irregular nodules. The majority of small-size (
ISSN:0033-8362
1826-6983
DOI:10.1007/s11547-013-0926-y