Properties of simian virus 40 mutants lacking the Asp sub(4)-Glu-Asp stretch at the carboxyl-terminus of large T antigen

Properties of simian virus 40 mutants lacking the Asp sub(4)-Glu-Asp stretch at the carboxyl-terminus of large T antigen

The biological activity carried by the carboxyl-terminal domain of SV40 large T antigen has been investigated by isolating mutants deleted for a stretch of six acidic residues which by analogy with polyoma middle T antigen might be essential for the activity of the protein. The authors have construc...

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Veröffentlicht in:Virology (New York, N.Y.) N.Y.), 1987-01, Vol.160 (2), p.485-488
Hauptverfasser: Pecceu, F, Komly, A, Gardes, M, Feunteun, J
Format: Artikel
Sprache:eng
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Zusammenfassung:The biological activity carried by the carboxyl-terminal domain of SV40 large T antigen has been investigated by isolating mutants deleted for a stretch of six acidic residues which by analogy with polyoma middle T antigen might be essential for the activity of the protein. The authors have constructed an "in-phase" deletion of 37 residues that includes the complete acid residues cluster.
ISSN:0042-6822