The first NDM metallo-β-lactamase-producing Enterobacteriaceae isolate in Poland: evolution of IncFII-type plasmids carrying the bla(NDM-1) gene

The first NDM metallo-β-lactamase-producing Enterobacteriaceae isolate in Poland: evolution of IncFII-type plasmids carrying the bla(NDM-1) gene

Poland's first Enterobacteriaceae isolate producing the New Delhi metallo-β-lactamase (NDM) was identified in August 2011. Escherichia coli sequence type ST410 NDM-1 was cultured from a critically ill patient who had been transferred directly from the Congo. The blaNDM-1 gene was carried by con...

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Veröffentlicht in:Antimicrobial agents and chemotherapy 2014, Vol.58 (2), p.1203-1207
Hauptverfasser: Fiett, J, Baraniak, A, Izdebski, R, Sitkiewicz, I, Żabicka, D, Meler, A, Filczak, K, Hryniewicz, W, Gniadkowski, M
Format: Artikel
Sprache:eng
Schlagworte:
Anti-Bacterial Agents - therapeutic use
beta-Lactamases - genetics
Drug Resistance, Multiple, Bacterial
Escherichia coli - genetics
Escherichia coli - isolation & purification
Escherichia coli Infections - drug therapy
Escherichia coli Infections - microbiology
Escherichia coli Infections - pathology
Fatal Outcome
Gene Expression
Humans
Male
Middle Aged
Multilocus Sequence Typing
Plasmids - chemistry
Poland
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Zusammenfassung:Poland's first Enterobacteriaceae isolate producing the New Delhi metallo-β-lactamase (NDM) was identified in August 2011. Escherichia coli sequence type ST410 NDM-1 was cultured from a critically ill patient who had been transferred directly from the Congo. The blaNDM-1 gene was carried by conjugative IncFII-type plasmid pMC-NDM (87,619 bp), which showed structural similarity to plasmid pGUE-NDM, which was identified earlier in France in an E. coli ST131 isolate of Indian origin.
ISSN:1098-6596
DOI:10.1128/AAC.01197-13