Abuse of methylphenidate in Germany: Data from spontaneous reports of adverse drug reactions

Abstract To retrieve insights into abuse/dependence of methylphenidate (MPH) in Germany, a query of a pharmacovigilance database was performed (observation interval: 1993 until 2012). From 1190 reports of any ADR related to MPH, n =23 (2%) cases of MPH abuse were identified (mean age 29 years; male...

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Veröffentlicht in:	Psychiatry research 2014-01, Vol.215 (1), p.252-254
Hauptverfasser:	Gahr, Maximilian, Freudenmann, Roland W, Hiemke, Christoph, Kölle, Markus A, Schönfeldt-Lecuona, Carlos
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Adverse Drug Reaction Reporting Systems Amphetamine-Related Disorders - epidemiology Attention Deficit Disorder with Hyperactivity - drug therapy Attention deficit disorders. Hyperactivity Attention deficit hyperactivity disorder Biological and medical sciences Central Nervous System Stimulants - therapeutic use Child Child clinical studies Databases, Factual Delayed-Action Preparations Female Germany Humans Male Medical sciences Methylphenidate - therapeutic use Middle Aged Neuroenhancement Neuropharmacology Pharmacology. Drug treatments Pharmacovigilance Prevalence Psychiatry Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychopharmacology Young Adult
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Zusammenfassung:	Abstract To retrieve insights into abuse/dependence of methylphenidate (MPH) in Germany, a query of a pharmacovigilance database was performed (observation interval: 1993 until 2012). From 1190 reports of any ADR related to MPH, n =23 (2%) cases of MPH abuse were identified (mean age 29 years; male sex 78%; mean daily MPH-dosage 111±126.6 mg). As oral application was predominant (70%), the majority of reported cases of MPH abuse might be due to pharmacologic neuroenhancement.
ISSN:	0165-1781 1872-7123
DOI:	10.1016/j.psychres.2013.11.008