Fish Oil (SMOFlipid) and Olive Oil Lipid (Clinoleic) in Very Preterm Neonates

ABSTRACT Objectives: Fat emulsions used in Australia for parenteral nutrition in preterm neonates have been based on either soybean oil or olive oil (OO). OO lipid Clinoleic has a high ratio of n‐6 to n‐3 fatty acids (9:1); this may not be ideal for long‐chain polyunsaturated fatty acids supply. Newly available SMOFlipid has an appropriate ratio of n‐6 to n‐3 fatty acids (2.5:1). SMOFlipid also contains OO (25%), coconut oil (30%), and soybean oil (30%). The aims of the study were to evaluate the safety of the SMOFlipid and to test the hypothesis that SMOFlipid would lead to increased omega‐3 long‐chain polyunsaturated fatty acid levels and reduced oxidative stress as compared with Clinoleic in preterm neonates (