EBV associated lymphomas in 2008 WHO classification

Epstein-Barr virus (EBV) is a ubiquitous γ-herpes virus that asymptomatically infects more than 90% of the world's population. The exact mechanism of EBV in oncogenesis is an area of active debate. However, EBV has been implicated in the pathogenesis of several kinds of lymphomas and lymphoprol...

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Veröffentlicht in:	Pathology, research and practice research and practice, 2014-02, Vol.210 (2), p.69-73
Hauptverfasser:	Zhang, Tiantian, Fu, Qianqian, Gao, Dalin, Ge, Liyan, Sun, Lin, Zhai, Qiongli
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors B-cell lymphomas Diagnosis, Differential Epstein-Barr virus Epstein-Barr Virus Infections - classification Epstein-Barr Virus Infections - pathology Epstein-Barr Virus Infections - therapy Herpesvirus 4, Human - physiology Hodgkin Disease - classification Hodgkin Disease - pathology Hodgkin Disease - therapy Hodgkin Disease - virology Hodgkin lymphoma Humans Lymphoma, B-Cell - classification Lymphoma, B-Cell - pathology Lymphoma, B-Cell - therapy Lymphoma, B-Cell - virology Lymphoma, Extranodal NK-T-Cell - classification Lymphoma, Extranodal NK-T-Cell - pathology Lymphoma, Extranodal NK-T-Cell - therapy Lymphoma, Extranodal NK-T-Cell - virology NK/T cell lymphomas Sex Factors World Health Organization
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Zusammenfassung:	Epstein-Barr virus (EBV) is a ubiquitous γ-herpes virus that asymptomatically infects more than 90% of the world's population. The exact mechanism of EBV in oncogenesis is an area of active debate. However, EBV has been implicated in the pathogenesis of several kinds of lymphomas and lymphoproliferative disorders, including B-, T- and NK-cell derived. Subsequent studies have proven that the EBV gene expression product plays an activating and/or promoting role on lymphomagenesis, and paves the way for novel cellular therapies of EBV-associated lymphomas. This review concentrates on the pathology, morphology, treatment and prognosis of EBV-associated lymphomas in the 2008 WHO classification of tumors of hematopoietic and lymphoma tissues.
ISSN:	0344-0338 1618-0631
DOI:	10.1016/j.prp.2013.11.009