Prospects for new antibiotics: a molecule-centered perspective

There is a continuous need for iterative cycles of antibiotic discovery and development to deal with the selection of resistant pathogens that emerge as therapeutic application of an antibiotic becomes widespread. A short golden age of antibiotic discovery from nature followed by a subsequent golden...

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Veröffentlicht in:Journal of antibiotics 2014-01, Vol.67 (1), p.7-22
Hauptverfasser: Walsh, Christopher T, Wencewicz, Timothy A
Format: Artikel
Sprache:eng
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Zusammenfassung:There is a continuous need for iterative cycles of antibiotic discovery and development to deal with the selection of resistant pathogens that emerge as therapeutic application of an antibiotic becomes widespread. A short golden age of antibiotic discovery from nature followed by a subsequent golden half century of medicinal chemistry optimization of existing molecular scaffolds emphasizes the need for new antibiotic molecular frameworks. We bring a molecule-centered perspective to the questions of where will new scaffolds come from, when will chemogenetic approaches yield useful new antibiotics and what existing bacterial targets merit contemporary re-examination.
ISSN:0021-8820
1881-1469
DOI:10.1038/ja.2013.49