Repeated forced swim stress enhances CFA-evoked thermal hyperalgesia and affects the expressions of pCREB and c-Fos in the insular cortex

Highlights • Forced swim stress increased the expressions of pCREB and c-Fos in the IC. • CFA injection after forced swim stress significantly enhanced thermal hyperalgesia. • CFA injection after forced swim stress decreased the expression of c-Fos in the IC. • These findings suggest a neuroplastic...

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Veröffentlicht in:	Neuroscience 2014-02, Vol.259, p.1-11
Hauptverfasser:	Imbe, H, Kimura, A, Donishi, T, Kaneoke, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anterior cingulate cortex Biological and medical sciences c-Fos Cerebral Cortex - metabolism CREB-Binding Protein - genetics CREB-Binding Protein - metabolism Disease Models, Animal forced swim stress Freund's Adjuvant - toxicity Functional Laterality Fundamental and applied biological sciences. Psychology hyperalgesia Hyperalgesia - chemically induced Hyperalgesia - complications Hyperalgesia - pathology Inflammation - etiology insular cortex Male Medical sciences Nervous system (semeiology, syndromes) Nervous system as a whole Neurology Pain Measurement Pain Threshold pCREB Proto-Oncogene Proteins c-fos - genetics Proto-Oncogene Proteins c-fos - metabolism Rats Rats, Sprague-Dawley Stress, Psychological - physiopathology Swimming - psychology Vertebrates: nervous system and sense organs
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Zusammenfassung:	Highlights • Forced swim stress increased the expressions of pCREB and c-Fos in the IC. • CFA injection after forced swim stress significantly enhanced thermal hyperalgesia. • CFA injection after forced swim stress decreased the expression of c-Fos in the IC. • These findings suggest a neuroplastic change in the IC after forced swim stress.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.11.045