The chemokine CCL5 induces CCR1-mediated hyperalgesia in mice inoculated with NCTC 2472 tumoral cells

Highlights • CCR1 blockade inhibits the hyperalgesia evoked by NCTC 2472 but not B16-F10 cells. • The antihyperalgesic effect is mediated at tumoral level and not at the spinal cord. • Spinal and tumoral CCL3 levels are unchanged in mice inoculated with tumoral cells. • CCL5 levels are increased in...

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Veröffentlicht in:	Neuroscience 2014-02, Vol.259, p.113-125
Hauptverfasser:	Pevida, M, Lastra, A, Meana, Á, Hidalgo, A, Baamonde, A, Menéndez, Luis
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Biological and medical sciences bone cancer-induced pain Bone Neoplasms - complications CCL5 CCR1 Cell Line, Tumor Chemokine CCL5 - antagonists & inhibitors Chemokine CCL5 - metabolism Disease Models, Animal Diseases of the osteoarticular system Dose-Response Relationship, Drug Enzyme-Linked Immunosorbent Assay Functional Laterality Gene Expression Regulation, Neoplastic - physiology hyperalgesia Hyperalgesia - blood Hyperalgesia - etiology Hyperalgesia - metabolism J113863 Male Medical sciences Mice Mice, Inbred C3H Mice, Inbred C57BL mouse Neoplasm Transplantation - adverse effects Nervous system (semeiology, syndromes) Nervous system as a whole Neurology Pain Measurement - drug effects Pain Threshold - drug effects Pain Threshold - physiology Peptide T - therapeutic use Receptors, CCR1 - antagonists & inhibitors Receptors, CCR1 - metabolism Tumors of striated muscle and skeleton Xanthenes - therapeutic use
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Zusammenfassung:	Highlights • CCR1 blockade inhibits the hyperalgesia evoked by NCTC 2472 but not B16-F10 cells. • The antihyperalgesic effect is mediated at tumoral level and not at the spinal cord. • Spinal and tumoral CCL3 levels are unchanged in mice inoculated with tumoral cells. • CCL5 levels are increased in tumors evoked by NCTC 2472 but not B16-F10 cells. • The administration of an anti-CCL5 antibody inhibits NCTC 2472-evoked hyperalgesia.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.11.055