EFFECT OF VIMLIV ON LIPID PEROXIDES AND ANTIOXIDANTS IN ETHANOL INDUCED HEPATOTOXICITY IN ALBINO WISTER RATS

This study was carried out to investigate the hepatoprotective and antioxidant properties of vimliv in ethanol-induced hepatotoxicity in rats. The liver toxicity was induced by the administration of ethanol to the animals at dose of 3 g/kg orally for 35 days. During the period of vimliv was co-administered to the rats at doses of 25 and 50 mg/kg for 35 days. The levels of lipidperoxidative products significantly increased and the levels of antioxidants decreased in ethanol induced rats. Co-administration of vimliv to ethanol-induced rats were significantly minimized the alterations in the levels of lipidperoxidation and antioxidatns. Administration of vimliv protected the liver against ethanol-induced toxicity, possibly by reducing the rate of lipidperoxidation and increasing the antioxidant defense mechanism in rats.