STUDY OF PROGNOSTIC SIGNIFICANCE OF SERUM C-REACTIVE PROTIEN AND ESR IN ACUTE ISCHEMIC STROKE

Background of the study: The stroke is defined as rapidly developing clinical signs of focal or global disturbance of cerebral function, lasting more than 24 hrs or leading to death, with no apparent cause other than vascular origin.1,2 An increasing body of evidence has linked inflammation with the pathogenesis of atherothrombotic stroke. The serum C-reactive protien (CRP) and ESR are acute-phase reactants, are indicators of underlying inflammation of endothelium and novel plasma markers for atherothrombotic disease.3,4,5 Aims and objectives: 1. To study the serum concentration of C-Reactive Protein [CRP] and ESR in patients of Acute ischemic stroke. 2. To compare it with that of age and sex matched controls. 3. One month follow up of the cases to know the results of stroke. Methods: It is a case control study, in this 50 cases, who has CT brain confirmed, first attack of Acute ischemic stroke and 50 healthy controls were taken. For all patients CRP and ESR levels were measured, with in 72 hours of onset of stroke and followed up for one month to know the results of cases. Results: The mean serum CRP level among the cases was 4.5 plus or minus 2.58mg/L and that among the controls it was 0.88 plus or minus 0.41 mg/L with the p value of < 0.001. There were 88% (44) of cases and 24% (12) of controls has CRP levels >0.8mg/L and 12%(6) of cases and 76%(38) of controls has CRP levels