Physical training prevents oxidative stress in L-NAME-induced hypertension rats
The present study investigated the effects of a 6‐week swimming training on blood pressure, nitric oxide (NO) levels and oxidative stress parameters such as protein and lipid oxidation, antioxidant enzyme activity and endogenous non‐enzymatic antioxidant content in kidney and circulating fluids, as...
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| Veröffentlicht in: | Cell biochemistry and function 2013-03, Vol.31 (2), p.136-151 |
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| creator | Cardoso, Andréia Machado Martins, Caroline Curry Fiorin, Fernando da Silva Schmatz, Roberta Abdalla, Fátima Husein Gutierres, Jessié Zanini, Daniela Fiorenza, Amanda Maino Stefanello, Naiara Serres, Jonas Daci da Silva Carvalho, Fabiano Castro, Verônica Paiva Mazzanti, Cinthia Melazzo Royes, Luiz Fernando Freire Belló-Klein, Adriane Goularte, Jeferson Ferraz Morsch, Vera Maria Bagatini, Margarete Dulce Schetinger, Maria Rosa Chitolina |
| description | The present study investigated the effects of a 6‐week swimming training on blood pressure, nitric oxide (NO) levels and oxidative stress parameters such as protein and lipid oxidation, antioxidant enzyme activity and endogenous non‐enzymatic antioxidant content in kidney and circulating fluids, as well as on serum biochemical parameters (cholesterol, triglycerides, urea and creatinine) from Nω‐nitro‐L‐arginine methyl ester hydrochloride (L‐NAME)‐induced hypertension treated rats. Animals were divided into four groups (n = 10): Control, Exercise, L‐NAME and Exercise L‐NAME. Results showed that exercise prevented a decrease in NO levels in hypertensive rats (P |
| doi_str_mv | 10.1002/cbf.2868 |
| format | Article |
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Animals were divided into four groups (n = 10): Control, Exercise, L‐NAME and Exercise L‐NAME. Results showed that exercise prevented a decrease in NO levels in hypertensive rats (P < 0·05). An increase in protein and lipid oxidation observed in the L‐NAME‐treated group was reverted by physical training in serum from the Exercise L‐NAME group (P < 0·05). A decrease in the catalase (CAT) and superoxide dismutase (SOD) activities in the L‐NAME group was observed when compared with normotensive groups (P < 0·05). In kidney, exercise significantly augmented the CAT and SOD activities in the Exercise L‐NAME group when compared with the L‐NAME group (P < 0·05). There was a decrease in the non‐protein thiols (NPSH) levels in the L‐NAME‐treated group when compared with the normotensive groups (P < 0·05). In the Exercise L‐NAME group, there was an increase in NPSH levels when compared with the L‐NAME group (P < 0·05). The elevation in serum cholesterol, triglycerides, urea and creatinine levels observed in the L‐NAME group were reverted to levels close to normal by exercise in the Exercise L‐NAME group (P < 0·05). Exercise training had hypotensive effect, reducing blood pressure in the Exercise L‐NAME group (P < 0·05). These findings suggest that physical training could have a protector effect against oxidative damage and renal injury caused by hypertension. Copyright © 2012 John Wiley & Sons, Ltd.]]></description><identifier>ISSN: 0263-6484</identifier><identifier>EISSN: 1099-0844</identifier><identifier>DOI: 10.1002/cbf.2868</identifier><identifier>PMID: 22961602</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Animal subjects ; Animals ; Ascorbic Acid - metabolism ; Biomarkers - metabolism ; Blood Pressure ; Body Weight ; Catalase - blood ; Heart Rate ; hypertension ; Hypertension - blood ; Hypertension - pathology ; Hypertension - physiopathology ; kidney ; Kidney - enzymology ; Kidney - pathology ; Lipid Peroxidation ; Lipids - blood ; Male ; NG-Nitroarginine Methyl Ester ; Nitric Oxide - metabolism ; Oxidation-Reduction ; Oxidative Stress ; Physical Conditioning, Animal ; physical training ; Protein Carbonylation ; Rats ; Rats, Wistar ; Sulfhydryl Compounds - blood ; Superoxide Dismutase - blood ; Swimming ; Systole ; Thiobarbituric Acid Reactive Substances - metabolism</subject><ispartof>Cell biochemistry and function, 2013-03, Vol.31 (2), p.136-151</ispartof><rights>Copyright © 2012 John Wiley & Sons, Ltd.</rights><rights>Copyright © 2013 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4868-109553363e536f0325e567d6bd1a3bb67fbef5d8a40fa8e78b7c0cf1cc554c863</citedby><cites>FETCH-LOGICAL-c4868-109553363e536f0325e567d6bd1a3bb67fbef5d8a40fa8e78b7c0cf1cc554c863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcbf.2868$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcbf.2868$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,27933,27934,45583,45584</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22961602$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cardoso, Andréia Machado</creatorcontrib><creatorcontrib>Martins, Caroline Curry</creatorcontrib><creatorcontrib>Fiorin, Fernando da Silva</creatorcontrib><creatorcontrib>Schmatz, Roberta</creatorcontrib><creatorcontrib>Abdalla, Fátima Husein</creatorcontrib><creatorcontrib>Gutierres, Jessié</creatorcontrib><creatorcontrib>Zanini, Daniela</creatorcontrib><creatorcontrib>Fiorenza, Amanda Maino</creatorcontrib><creatorcontrib>Stefanello, Naiara</creatorcontrib><creatorcontrib>Serres, Jonas Daci da Silva</creatorcontrib><creatorcontrib>Carvalho, Fabiano</creatorcontrib><creatorcontrib>Castro, Verônica Paiva</creatorcontrib><creatorcontrib>Mazzanti, Cinthia Melazzo</creatorcontrib><creatorcontrib>Royes, Luiz Fernando Freire</creatorcontrib><creatorcontrib>Belló-Klein, Adriane</creatorcontrib><creatorcontrib>Goularte, Jeferson Ferraz</creatorcontrib><creatorcontrib>Morsch, Vera Maria</creatorcontrib><creatorcontrib>Bagatini, Margarete Dulce</creatorcontrib><creatorcontrib>Schetinger, Maria Rosa Chitolina</creatorcontrib><title>Physical training prevents oxidative stress in L-NAME-induced hypertension rats</title><title>Cell biochemistry and function</title><addtitle>Cell Biochem Funct</addtitle><description><![CDATA[The present study investigated the effects of a 6‐week swimming training on blood pressure, nitric oxide (NO) levels and oxidative stress parameters such as protein and lipid oxidation, antioxidant enzyme activity and endogenous non‐enzymatic antioxidant content in kidney and circulating fluids, as well as on serum biochemical parameters (cholesterol, triglycerides, urea and creatinine) from Nω‐nitro‐L‐arginine methyl ester hydrochloride (L‐NAME)‐induced hypertension treated rats. Animals were divided into four groups (n = 10): Control, Exercise, L‐NAME and Exercise L‐NAME. Results showed that exercise prevented a decrease in NO levels in hypertensive rats (P < 0·05). An increase in protein and lipid oxidation observed in the L‐NAME‐treated group was reverted by physical training in serum from the Exercise L‐NAME group (P < 0·05). A decrease in the catalase (CAT) and superoxide dismutase (SOD) activities in the L‐NAME group was observed when compared with normotensive groups (P < 0·05). In kidney, exercise significantly augmented the CAT and SOD activities in the Exercise L‐NAME group when compared with the L‐NAME group (P < 0·05). There was a decrease in the non‐protein thiols (NPSH) levels in the L‐NAME‐treated group when compared with the normotensive groups (P < 0·05). In the Exercise L‐NAME group, there was an increase in NPSH levels when compared with the L‐NAME group (P < 0·05). The elevation in serum cholesterol, triglycerides, urea and creatinine levels observed in the L‐NAME group were reverted to levels close to normal by exercise in the Exercise L‐NAME group (P < 0·05). Exercise training had hypotensive effect, reducing blood pressure in the Exercise L‐NAME group (P < 0·05). These findings suggest that physical training could have a protector effect against oxidative damage and renal injury caused by hypertension. Copyright © 2012 John Wiley & Sons, Ltd.]]></description><subject>Animal subjects</subject><subject>Animals</subject><subject>Ascorbic Acid - metabolism</subject><subject>Biomarkers - metabolism</subject><subject>Blood Pressure</subject><subject>Body Weight</subject><subject>Catalase - blood</subject><subject>Heart Rate</subject><subject>hypertension</subject><subject>Hypertension - blood</subject><subject>Hypertension - pathology</subject><subject>Hypertension - physiopathology</subject><subject>kidney</subject><subject>Kidney - enzymology</subject><subject>Kidney - pathology</subject><subject>Lipid Peroxidation</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>NG-Nitroarginine Methyl Ester</subject><subject>Nitric Oxide - metabolism</subject><subject>Oxidation-Reduction</subject><subject>Oxidative Stress</subject><subject>Physical Conditioning, Animal</subject><subject>physical training</subject><subject>Protein Carbonylation</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Sulfhydryl Compounds - blood</subject><subject>Superoxide Dismutase - blood</subject><subject>Swimming</subject><subject>Systole</subject><subject>Thiobarbituric Acid Reactive Substances - metabolism</subject><issn>0263-6484</issn><issn>1099-0844</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtLHEEURguJ6MQI-QWhIZtsWm89u3ppJr5g1EASAm6K6urbsUxP9aSq2zj_PiVODAjB1d0cDt_lEPKWwgEFYIeu6Q6YVnqLzCjUdQlaiFdkBkzxUgktdsnrlG4BoFYcdsguY7WiCtiMXH2-WSfvbF-M0frgw49iFfEOw5iK4d63dvR3WKQxYkqFD8WivDy6OC59aCeHbXGzXmEcMSQ_hCLaMb0h253tE-5v7h75dnL8dX5WLq5Oz-dHi9KJvLPMK6XkXHGUXHXAmUSpqlY1LbW8aVTVNdjJVlsBndVY6aZy4DrqnJTCacX3yIdH7yoOvyZMo1n65LDvbcBhSoaKOj-vuYaXUU6FrpkAntH3z9DbYYohP5KFSrKKguL_hC4OKUXszCr6pY1rQ8E89DC5h3nokdF3G-HULLF9Av8GyED5CPz2Pa7_KzLzjycb4Yb3acT7J97Gn0ZVvJLm--WpUbyuPl1c1-YL_wMi0qFI</recordid><startdate>201303</startdate><enddate>201303</enddate><creator>Cardoso, Andréia Machado</creator><creator>Martins, Caroline Curry</creator><creator>Fiorin, Fernando da Silva</creator><creator>Schmatz, Roberta</creator><creator>Abdalla, Fátima Husein</creator><creator>Gutierres, Jessié</creator><creator>Zanini, Daniela</creator><creator>Fiorenza, Amanda Maino</creator><creator>Stefanello, Naiara</creator><creator>Serres, Jonas Daci da Silva</creator><creator>Carvalho, Fabiano</creator><creator>Castro, Verônica Paiva</creator><creator>Mazzanti, Cinthia Melazzo</creator><creator>Royes, Luiz Fernando Freire</creator><creator>Belló-Klein, Adriane</creator><creator>Goularte, Jeferson Ferraz</creator><creator>Morsch, Vera Maria</creator><creator>Bagatini, Margarete Dulce</creator><creator>Schetinger, Maria Rosa Chitolina</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>7TS</scope></search><sort><creationdate>201303</creationdate><title>Physical training prevents oxidative stress in L-NAME-induced hypertension rats</title><author>Cardoso, Andréia Machado ; Martins, Caroline Curry ; Fiorin, Fernando da Silva ; Schmatz, Roberta ; Abdalla, Fátima Husein ; Gutierres, Jessié ; Zanini, Daniela ; Fiorenza, Amanda Maino ; Stefanello, Naiara ; Serres, Jonas Daci da Silva ; Carvalho, Fabiano ; Castro, Verônica Paiva ; Mazzanti, Cinthia Melazzo ; Royes, Luiz Fernando Freire ; Belló-Klein, Adriane ; Goularte, Jeferson Ferraz ; Morsch, Vera Maria ; Bagatini, Margarete Dulce ; Schetinger, Maria Rosa Chitolina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4868-109553363e536f0325e567d6bd1a3bb67fbef5d8a40fa8e78b7c0cf1cc554c863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animal subjects</topic><topic>Animals</topic><topic>Ascorbic Acid - 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Animals were divided into four groups (n = 10): Control, Exercise, L‐NAME and Exercise L‐NAME. Results showed that exercise prevented a decrease in NO levels in hypertensive rats (P < 0·05). An increase in protein and lipid oxidation observed in the L‐NAME‐treated group was reverted by physical training in serum from the Exercise L‐NAME group (P < 0·05). A decrease in the catalase (CAT) and superoxide dismutase (SOD) activities in the L‐NAME group was observed when compared with normotensive groups (P < 0·05). In kidney, exercise significantly augmented the CAT and SOD activities in the Exercise L‐NAME group when compared with the L‐NAME group (P < 0·05). There was a decrease in the non‐protein thiols (NPSH) levels in the L‐NAME‐treated group when compared with the normotensive groups (P < 0·05). In the Exercise L‐NAME group, there was an increase in NPSH levels when compared with the L‐NAME group (P < 0·05). The elevation in serum cholesterol, triglycerides, urea and creatinine levels observed in the L‐NAME group were reverted to levels close to normal by exercise in the Exercise L‐NAME group (P < 0·05). Exercise training had hypotensive effect, reducing blood pressure in the Exercise L‐NAME group (P < 0·05). These findings suggest that physical training could have a protector effect against oxidative damage and renal injury caused by hypertension. Copyright © 2012 John Wiley & Sons, Ltd.]]></abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>22961602</pmid><doi>10.1002/cbf.2868</doi><tpages>16</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0263-6484 |
| ispartof | Cell biochemistry and function, 2013-03, Vol.31 (2), p.136-151 |
| issn | 0263-6484 1099-0844 |
| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Animal subjects Animals Ascorbic Acid - metabolism Biomarkers - metabolism Blood Pressure Body Weight Catalase - blood Heart Rate hypertension Hypertension - blood Hypertension - pathology Hypertension - physiopathology kidney Kidney - enzymology Kidney - pathology Lipid Peroxidation Lipids - blood Male NG-Nitroarginine Methyl Ester Nitric Oxide - metabolism Oxidation-Reduction Oxidative Stress Physical Conditioning, Animal physical training Protein Carbonylation Rats Rats, Wistar Sulfhydryl Compounds - blood Superoxide Dismutase - blood Swimming Systole Thiobarbituric Acid Reactive Substances - metabolism |
| title | Physical training prevents oxidative stress in L-NAME-induced hypertension rats |
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