The polymorphisms of the MBL2 and MIF genes associated with Pediatric Cochlear Implant Patients

Abstract Objectives Mannose-binding lectin and macrophage migration inhibitory factor gene polymorphisms are associated with several acute/chronic autoimmune or inflammatory diseases. The aim of this study was to investigate if there was any association between mannose-binding lectin 2 (MBL2) and macrophage migration inhibitory factor (MIF) gene polymorphisms and profound congenital sensorineural hearing loss in children who underwent cochlear implantation. Methods A total of 62 patients with congenital hearing loss and 80 age- and sex-matched healthy controls were evaluated for codon 54 A/B polymorphisms in MBL2 and the-173 G/C polymorphism in MIF by using the polymerase chain reaction and restriction fragment length polymorphism method. Results The frequency of the BB genotype of MBL2 and MIF −173 GC genotype were statistically significantly higher in the patient group than in the controls ( p = 0.0127, p = 0.0408, respectively). Conclusion In this study, we found that a subject who is homozygous for the variant allele B of codon 54 of the MBL2and heterozygous for variant allele C of −173 MIF has a risk factor for sensorineural hearing loss.