Amphiphilically modified chitosan cationic nanoparticles for drug delivery

A series of amphiphilic N -(2-hydroxy)propyl-3-trimethylammonium-chitosan-cholic acid (HPTA-CHI-CA) polymers were synthesized by grafting cholic acid (CA) and glycidyltrimethylammonium chloride onto chitosan. The self-assembly behavior of HPTA-CHI-CA was studied by fluorescence technique. The polyme...

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Veröffentlicht in:	Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology 2013-12, Vol.15 (12), p.1-10, Article 2123
Hauptverfasser:	You, Jie, Li, Wenfeng, Yu, Chang, Zhao, Chengguang, Jin, Langping, Zhou, Yili, Xu, Xuzhong, Dong, Siyang, Lu, Xincheng, Wang, Ouchen
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biotechnology Characterization and Evaluation of Materials Chemistry and Materials Science Cross-disciplinary physics: materials science rheology Exact sciences and technology Fundamental and applied biological sciences. Psychology Inorganic Chemistry Lasers Materials Science Methods of nanofabrication Methods. Procedures. Technologies Nanocrystalline materials Nanoparticles Nanoscale materials and structures: fabrication and characterization Nanotechnology Optical Devices Optics Others Photonics Physical Chemistry Physics Polymers Research Paper Self-assembly Various methods and equipments
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Zusammenfassung:	A series of amphiphilic N -(2-hydroxy)propyl-3-trimethylammonium-chitosan-cholic acid (HPTA-CHI-CA) polymers were synthesized by grafting cholic acid (CA) and glycidyltrimethylammonium chloride onto chitosan. The self-assembly behavior of HPTA-CHI-CA was studied by fluorescence technique. The polymers were able to self-assemble into NPs in phosphate buffered saline with a critical aggregation concentration (CAC) in the range of 66–26 mg/L and the CAC decreased with the increasing of the degree of substitution (DS) of CA. The size of cationic HPTA-CHI-CA NPs ranges from 170 to 220 nm (PDI
ISSN:	1388-0764 1572-896X
DOI:	10.1007/s11051-013-2123-2