Effects of Polymorphisms of NOS3 and GNB3 Genes on Skin Microvascular Reactivity in Normal Pregnancy
We studied the relationship between endothelial NO-synthase gene ( NOS3 ) and G protein β3 subunit gene ( GNB3 ) polymorphisms and reactivity of skin microvessels during physiological gestation. T-786C NOS3 polymorphism influenced the maximum blood flow rate in skin microvessels and the severity of...
Gespeichert in:
| Veröffentlicht in: | Bulletin of experimental biology and medicine 2013-05, Vol.155 (1), p.81-84 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 84 |
|---|---|
| container_issue | 1 |
| container_start_page | 81 |
| container_title | Bulletin of experimental biology and medicine |
| container_volume | 155 |
| creator | Radkov, O. V. Volf, Ju. V. |
| description | We studied the relationship between endothelial NO-synthase gene (
NOS3
) and G protein β3 subunit gene (
GNB3
) polymorphisms and reactivity of skin microvessels during physiological gestation.
T-786C NOS3
polymorphism influenced the maximum blood flow rate in skin microvessels and the severity of postocclusive reactive hyperemia during the third trimester of pregnancy. The relationship between
G894T NOS3
polymorphism and the duration of postocclusive reactive hyperemia was revealed.
C825T GNB3
polymorphism affects the duration and severity of postocclusive reactive hyperemia during the first and third trimesters of pregnancy. Thus,
NOS3
and
GNB3
polymorphisms affect blood flow in the skin microvessels during physiological gestation. |
| doi_str_mv | 10.1007/s10517-013-2085-5 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1492633829</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A339428046</galeid><sourcerecordid>A339428046</sourcerecordid><originalsourceid>FETCH-LOGICAL-c455t-7db451bddfc53ef6d947d3657fc479dd66b46a635ff005fe6381cfda5d32bcce3</originalsourceid><addsrcrecordid>eNqFkl1rFDEYhYModq3-AG8kIIg3U_M9mcta6irUbbF6HbL52E2dSdZkprD_vtlu1VYUyUXIeZ9z4CUHgJcYHWGE2ncFI47bBmHaECR5wx-BGeYtbSQh-DGYoQo1TEp5AJ6VcrV7IoGfggNChWhlK2fAnnrvzFhg8vAi9dsh5c06lOFWWJxfUqijhfPFewrnLroqR3j5PUT4OZicrnUxU68z_OK0GcN1GLewzhYpD7qHF9mtoo5m-xw88bov7sXdfQi-fTj9evKxOTuffzo5PmsM43xsWrtkHC-t9YZT54XtWGup4K03rO2sFWLJhBaUe48Q905QiY23mltKlsY4egje7nM3Of2YXBnVEIpxfa-jS1NRmHVEUCpJ93-UciQ7wiSp6Os_0Ks05VgXqYGYMtRRQn9TK907FaJPY9ZmF6qOKe0YkYiJSh39harHuiGYFJ0PVX9geHPPsHa6H9cl9dMYUiwPQbwH67eUkp1XmxwGnbcKI7Vri9q3RdW2qF1bFK-eV3ebTcvB2V-On_WoANkDpY7iyuV7q_8z9QYyvcZ-</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1413409323</pqid></control><display><type>article</type><title>Effects of Polymorphisms of NOS3 and GNB3 Genes on Skin Microvascular Reactivity in Normal Pregnancy</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Radkov, O. V. ; Volf, Ju. V.</creator><creatorcontrib>Radkov, O. V. ; Volf, Ju. V.</creatorcontrib><description>We studied the relationship between endothelial NO-synthase gene (
NOS3
) and G protein β3 subunit gene (
GNB3
) polymorphisms and reactivity of skin microvessels during physiological gestation.
T-786C NOS3
polymorphism influenced the maximum blood flow rate in skin microvessels and the severity of postocclusive reactive hyperemia during the third trimester of pregnancy. The relationship between
G894T NOS3
polymorphism and the duration of postocclusive reactive hyperemia was revealed.
C825T GNB3
polymorphism affects the duration and severity of postocclusive reactive hyperemia during the first and third trimesters of pregnancy. Thus,
NOS3
and
GNB3
polymorphisms affect blood flow in the skin microvessels during physiological gestation.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-013-2085-5</identifier><identifier>PMID: 23667878</identifier><identifier>CODEN: BEXBAN</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adult ; Alleles ; Biomedical and Life Sciences ; Biomedicine ; Blood Flow Velocity ; Cell Biology ; Female ; Gene polymorphism ; Genes ; Genetic aspects ; Genetic research ; Genetics ; Genotype ; Heterotrimeric GTP-Binding Proteins - genetics ; Humans ; Hyperemia - genetics ; Internal Medicine ; Laboratory Medicine ; Microvessels - physiology ; Nitric Oxide Synthase Type III - genetics ; Pathology ; Physiological aspects ; Polymorphism, Single Nucleotide ; Pregnancy ; Pregnancy Trimester, First ; Pregnancy Trimester, Third ; Pregnant women ; Skin ; Skin - blood supply ; Young Adult</subject><ispartof>Bulletin of experimental biology and medicine, 2013-05, Vol.155 (1), p.81-84</ispartof><rights>Springer Science+Business Media New York 2013</rights><rights>COPYRIGHT 2013 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c455t-7db451bddfc53ef6d947d3657fc479dd66b46a635ff005fe6381cfda5d32bcce3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-013-2085-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-013-2085-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23667878$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Radkov, O. V.</creatorcontrib><creatorcontrib>Volf, Ju. V.</creatorcontrib><title>Effects of Polymorphisms of NOS3 and GNB3 Genes on Skin Microvascular Reactivity in Normal Pregnancy</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>We studied the relationship between endothelial NO-synthase gene (
NOS3
) and G protein β3 subunit gene (
GNB3
) polymorphisms and reactivity of skin microvessels during physiological gestation.
T-786C NOS3
polymorphism influenced the maximum blood flow rate in skin microvessels and the severity of postocclusive reactive hyperemia during the third trimester of pregnancy. The relationship between
G894T NOS3
polymorphism and the duration of postocclusive reactive hyperemia was revealed.
C825T GNB3
polymorphism affects the duration and severity of postocclusive reactive hyperemia during the first and third trimesters of pregnancy. Thus,
NOS3
and
GNB3
polymorphisms affect blood flow in the skin microvessels during physiological gestation.</description><subject>Adult</subject><subject>Alleles</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood Flow Velocity</subject><subject>Cell Biology</subject><subject>Female</subject><subject>Gene polymorphism</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic research</subject><subject>Genetics</subject><subject>Genotype</subject><subject>Heterotrimeric GTP-Binding Proteins - genetics</subject><subject>Humans</subject><subject>Hyperemia - genetics</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Microvessels - physiology</subject><subject>Nitric Oxide Synthase Type III - genetics</subject><subject>Pathology</subject><subject>Physiological aspects</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, First</subject><subject>Pregnancy Trimester, Third</subject><subject>Pregnant women</subject><subject>Skin</subject><subject>Skin - blood supply</subject><subject>Young Adult</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkl1rFDEYhYModq3-AG8kIIg3U_M9mcta6irUbbF6HbL52E2dSdZkprD_vtlu1VYUyUXIeZ9z4CUHgJcYHWGE2ncFI47bBmHaECR5wx-BGeYtbSQh-DGYoQo1TEp5AJ6VcrV7IoGfggNChWhlK2fAnnrvzFhg8vAi9dsh5c06lOFWWJxfUqijhfPFewrnLroqR3j5PUT4OZicrnUxU68z_OK0GcN1GLewzhYpD7qHF9mtoo5m-xw88bov7sXdfQi-fTj9evKxOTuffzo5PmsM43xsWrtkHC-t9YZT54XtWGup4K03rO2sFWLJhBaUe48Q905QiY23mltKlsY4egje7nM3Of2YXBnVEIpxfa-jS1NRmHVEUCpJ93-UciQ7wiSp6Os_0Ks05VgXqYGYMtRRQn9TK907FaJPY9ZmF6qOKe0YkYiJSh39harHuiGYFJ0PVX9geHPPsHa6H9cl9dMYUiwPQbwH67eUkp1XmxwGnbcKI7Vri9q3RdW2qF1bFK-eV3ebTcvB2V-On_WoANkDpY7iyuV7q_8z9QYyvcZ-</recordid><startdate>20130501</startdate><enddate>20130501</enddate><creator>Radkov, O. V.</creator><creator>Volf, Ju. V.</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20130501</creationdate><title>Effects of Polymorphisms of NOS3 and GNB3 Genes on Skin Microvascular Reactivity in Normal Pregnancy</title><author>Radkov, O. V. ; Volf, Ju. V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-7db451bddfc53ef6d947d3657fc479dd66b46a635ff005fe6381cfda5d32bcce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Alleles</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Blood Flow Velocity</topic><topic>Cell Biology</topic><topic>Female</topic><topic>Gene polymorphism</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genetic research</topic><topic>Genetics</topic><topic>Genotype</topic><topic>Heterotrimeric GTP-Binding Proteins - genetics</topic><topic>Humans</topic><topic>Hyperemia - genetics</topic><topic>Internal Medicine</topic><topic>Laboratory Medicine</topic><topic>Microvessels - physiology</topic><topic>Nitric Oxide Synthase Type III - genetics</topic><topic>Pathology</topic><topic>Physiological aspects</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, First</topic><topic>Pregnancy Trimester, Third</topic><topic>Pregnant women</topic><topic>Skin</topic><topic>Skin - blood supply</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Radkov, O. V.</creatorcontrib><creatorcontrib>Volf, Ju. V.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Bulletin of experimental biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Radkov, O. V.</au><au>Volf, Ju. V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Polymorphisms of NOS3 and GNB3 Genes on Skin Microvascular Reactivity in Normal Pregnancy</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><stitle>Bull Exp Biol Med</stitle><addtitle>Bull Exp Biol Med</addtitle><date>2013-05-01</date><risdate>2013</risdate><volume>155</volume><issue>1</issue><spage>81</spage><epage>84</epage><pages>81-84</pages><issn>0007-4888</issn><eissn>1573-8221</eissn><coden>BEXBAN</coden><abstract>We studied the relationship between endothelial NO-synthase gene (
NOS3
) and G protein β3 subunit gene (
GNB3
) polymorphisms and reactivity of skin microvessels during physiological gestation.
T-786C NOS3
polymorphism influenced the maximum blood flow rate in skin microvessels and the severity of postocclusive reactive hyperemia during the third trimester of pregnancy. The relationship between
G894T NOS3
polymorphism and the duration of postocclusive reactive hyperemia was revealed.
C825T GNB3
polymorphism affects the duration and severity of postocclusive reactive hyperemia during the first and third trimesters of pregnancy. Thus,
NOS3
and
GNB3
polymorphisms affect blood flow in the skin microvessels during physiological gestation.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>23667878</pmid><doi>10.1007/s10517-013-2085-5</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-4888 |
| ispartof | Bulletin of experimental biology and medicine, 2013-05, Vol.155 (1), p.81-84 |
| issn | 0007-4888 1573-8221 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1492633829 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Alleles Biomedical and Life Sciences Biomedicine Blood Flow Velocity Cell Biology Female Gene polymorphism Genes Genetic aspects Genetic research Genetics Genotype Heterotrimeric GTP-Binding Proteins - genetics Humans Hyperemia - genetics Internal Medicine Laboratory Medicine Microvessels - physiology Nitric Oxide Synthase Type III - genetics Pathology Physiological aspects Polymorphism, Single Nucleotide Pregnancy Pregnancy Trimester, First Pregnancy Trimester, Third Pregnant women Skin Skin - blood supply Young Adult |
| title | Effects of Polymorphisms of NOS3 and GNB3 Genes on Skin Microvascular Reactivity in Normal Pregnancy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T07%3A49%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20Polymorphisms%20of%20NOS3%20and%20GNB3%20Genes%20on%20Skin%20Microvascular%20Reactivity%20in%20Normal%20Pregnancy&rft.jtitle=Bulletin%20of%20experimental%20biology%20and%20medicine&rft.au=Radkov,%20O.%20V.&rft.date=2013-05-01&rft.volume=155&rft.issue=1&rft.spage=81&rft.epage=84&rft.pages=81-84&rft.issn=0007-4888&rft.eissn=1573-8221&rft.coden=BEXBAN&rft_id=info:doi/10.1007/s10517-013-2085-5&rft_dat=%3Cgale_proqu%3EA339428046%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1413409323&rft_id=info:pmid/23667878&rft_galeid=A339428046&rfr_iscdi=true |