Effects of Polymorphisms of NOS3 and GNB3 Genes on Skin Microvascular Reactivity in Normal Pregnancy

We studied the relationship between endothelial NO-synthase gene ( NOS3 ) and G protein β3 subunit gene ( GNB3 ) polymorphisms and reactivity of skin microvessels during physiological gestation. T-786C NOS3 polymorphism influenced the maximum blood flow rate in skin microvessels and the severity of postocclusive reactive hyperemia during the third trimester of pregnancy. The relationship between G894T NOS3 polymorphism and the duration of postocclusive reactive hyperemia was revealed. C825T GNB3 polymorphism affects the duration and severity of postocclusive reactive hyperemia during the first and third trimesters of pregnancy. Thus, NOS3 and GNB3 polymorphisms affect blood flow in the skin microvessels during physiological gestation.