Quantitative MRI and ultrastructural examination of the cuprizone mouse model of demyelination

The cuprizone mouse model of demyelination was used to investigate the influence that white matter changes have on different magnetic resonance imaging results. In vivo T2‐weighted and magnetization transfer images (MTIs) were acquired weekly in control (n = 5) and cuprizone‐fed (n = 5) mice, with s...

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Veröffentlicht in:	NMR in biomedicine 2013-11, Vol.26 (11), p.1562-1581
Hauptverfasser:	Thiessen, Jonathan D., Zhang, Yanbo, Zhang, Handi, Wang, Lingyan, Buist, Richard, Del Bigio, Marc R., Kong, Jiming, Li, Xin-Min, Martin, Melanie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Axons - pathology Axons - ultrastructure bound water fraction corpus callosum Corpus Callosum - pathology Corpus Callosum - ultrastructure Cuprizone Demyelinating Diseases - chemically induced Demyelinating Diseases - pathology demyelination Diet diffusion tensor imaging Disease Models, Animal electron microscopy Female Magnetic Resonance Imaging magnetization transfer imaging Mice Mice, Inbred C57BL Myelin Sheath - metabolism Perfusion Signal Processing, Computer-Assisted Statistics, Nonparametric T1/T2 relaxation time measurements
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Zusammenfassung:	The cuprizone mouse model of demyelination was used to investigate the influence that white matter changes have on different magnetic resonance imaging results. In vivo T2‐weighted and magnetization transfer images (MTIs) were acquired weekly in control (n = 5) and cuprizone‐fed (n = 5) mice, with significant increases in signal intensity in T2‐weighted images (p
ISSN:	0952-3480 1099-1492
DOI:	10.1002/nbm.2992