Osseointegration of implants with dendrimers surface characteristics installed conventionally or with Piezosurgery registered . A comparative study in the dog

The first aim of the present experiment was to compare bone healing at implants installed in recipient sites prepared with conventional drills or a piezoelectric device. The second aim was to compare implant osseointegration onto surfaces with and without dendrimers coatings. Six Beagles dogs were used in this study. Five implants with two different surfaces, three with a ZirTi registered surface (zirconia sand blasted, acid etched), and two with a ZirTi registered -modified surface with dendrimers of phosphoserine and polylysine were installed in the right side of the mandible. In the most anterior region (P2, P3), two recipient sites were prepared with drills, and one implant ZirTi registered surface and one coated with dendrimers implants were installed at random. In the posterior region (P4 and M1), three recipient sites were randomly prepared: two sites with a Piezosurgery registered instrument and one site with drill and two ZirTi registered surface and one coated with dendrimers implants installed. Three months after the surgery, the animals were sacrificed for histological analysis. No complications occurred during the healing period. Three implants were found not integrated and were excluded from analysis. However, n = 6 was obtained. The distance IS-B at the buccal aspect was 2.2 plus or minus 0.8 and 1.8 plus or minus 0.5 mm, while IS-C was 1.5 plus or minus 0.9 and 1.4 plus or minus 0.6 mm at the Piezosurgery registered and drill groups, respectively. Similar values were obtained between the dendrimers-coated and ZirTi registered surface implants. The BIC% values were higher at the drill (72%) compared to the Piezosurgery registered (67%) sites. The BIC% were also found to be higher at the ZirTi registered (74%) compared to the dendrimers-coated (65%) implants, the difference being statistically significant. This study has revealed that oral implants may osseointegrate equally well irrespective of whether their bed was prepared utilizing conventional drills with abundant cooling or Piezosurgery registered . Moreover, the surface coating of implants with dendrimers phosphoserine and polylysine did not improve osseointegration.