Pregnancy loss managed by cervical dilatation and curettage increases the risk of spontaneous preterm birth

STUDY QUESTION Do women with a previous miscarriage or termination of pregnancy have an increased risk of spontaneous preterm birth and is this related to previous cervical dilatation and curettage? SUMMARY ANSWER A single previous pregnancy loss (termination or miscarriage) managed by cervical dila...

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Veröffentlicht in:Human reproduction (Oxford) 2013-12, Vol.28 (12), p.3197-3206
Hauptverfasser: McCarthy, Fergus P., Khashan, Ali S., North, Robyn A., Rahma, Muna B., Walker, James J., Baker, Philip N., Dekker, Gus, Poston, Lucilla, McCowan, Lesley M.E., O'Donoghue, Keelin, Kenny, Louise C.
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Sprache:eng
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Zusammenfassung:STUDY QUESTION Do women with a previous miscarriage or termination of pregnancy have an increased risk of spontaneous preterm birth and is this related to previous cervical dilatation and curettage? SUMMARY ANSWER A single previous pregnancy loss (termination or miscarriage) managed by cervical dilatation and curettage is associated with a greater risk of SpPTB. WHAT IS KNOWN ALREADY Miscarriage affects ∼20% of pregnancies and as many as a further 20% of pregnancies undergo termination. STUDY DESIGN, SIZE, DURATION We utilized data from 5575 healthy nulliparous women with singleton pregnancies recruited to the Screening for Pregnancy Endpoints (SCOPE) study, a prospective cohort study performed between November 2004 and January 2011. PARTICIPANTS/MATERIALS, SETTING, METHODS The primary outcome was spontaneous preterm birth (defined as spontaneous preterm labour or preterm premature rupture of membranes (PPROM) resulting in preterm birth
ISSN:0268-1161
1460-2350
DOI:10.1093/humrep/det332