Live birth rates following in vitro fertilization in women with thyroid autoimmunity and/or subclinical hypothyroidism

Summary Objective To investigate whether the live birth rate following in vitro fertilization (IVF) is affected by thyroid autoimmunity (TAI) and/or subclinical hypothyroidism in subfertile women. Design and setting Retrospective study in a university infertility clinic. Patients A total of 627 women without past or current history of thyroid disorder undergoing their first IVF cycle. Intervention Pre‐IVF archived blood serum samples were tested for TAI and thyroid function tests. Main outcome measure Live birth rate. Results The clinical pregnancy rate, live birth rate and miscarriage rate were similar among women with or without TAI and/or subclinical hypothyroidism using a TSH threshold 4·5 mIU/l. Thyroid autoantibody level did not affect these IVF outcomes. Conclusion The live birth rate and miscarriage rate of women with TAI and/or subclinical hypothyroidism following IVF were not impaired.