Comparative Pharmacokinetics of Five Rhubarb Anthraquinones in Normal and Thrombotic Focal Cerebral Ischemia-Induced Rats

A comparative oral pharmacokinetic study of five anthraquinones (aloe‐emodin, emodin, rhein, chrysophanol and physcion) from the extract of Rheum palmatum L. was performed in normal and thrombotic focal cerebral ischemia (TFCI)‐induced rats. The plasma samples were clarified through solid phase extr...

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Veröffentlicht in:	Phytotherapy research 2013-10, Vol.27 (10), p.1489-1494
Hauptverfasser:	Feng, Su-xiang, Li, Jian-sheng, Qu, Ling-bo, Shi, Yan-mei, Zhao, Di
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anthraquinones Anthraquinones - pharmacokinetics Brain Ischemia - drug therapy Chromatography, High Pressure Liquid Chrysophanic acid Drugs, Chinese Herbal - pharmacokinetics Emodin - analogs & derivatives Emodin - pharmacokinetics Male normal rats pharmacokinetics comparison Plant Extracts - chemistry Plant Extracts - pharmacokinetics Rats Rats, Sprague-Dawley Rheum Rheum - chemistry rhubarb extract thrombotic focal cerebral ischemia-induced rats
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Zusammenfassung:	A comparative oral pharmacokinetic study of five anthraquinones (aloe‐emodin, emodin, rhein, chrysophanol and physcion) from the extract of Rheum palmatum L. was performed in normal and thrombotic focal cerebral ischemia (TFCI)‐induced rats. The plasma samples were clarified through solid phase extraction prior to simultaneous determination of the anthraquinones with a validated high‐performance liquid chromatography ‐fluorescence system. The results indicated that the Cmax, t1/2 and AUC0‐t, of aloe‐emodin, rhein, emodin and chrysophanol in TFCI‐induced rats were nearly double, whereas the CL values were remarkably decreased (p
ISSN:	0951-418X 1099-1573
DOI:	10.1002/ptr.4890