Synthesis and antimicrobial activity of [alpha]-aminoboronic-containing peptidomimetics

Synthesis and antimicrobial activity of [alpha]-aminoboronic-containing peptidomimetics

A library of 175 dipeptidomimetics and tripeptidomimetics containing an [alpha]-amino boronic acid or boronate has been synthesized, and the activity toward Mycobacterium tuberculosis, Candida albicans, Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli and Pseudomonas aeruginosa has be...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of peptide science 2014-01, Vol.20 (1), p.20-24
Hauptverfasser: Gozhina, Olga V, Svendsen, John Sigurd, Lejon, Tore
Format: Artikel
Sprache:eng
Schlagworte:
Candida albicans
Escherichia coli
Mycobacterium tuberculosis
Peptides
Pseudomonas aeruginosa
Staphylococcus aureus
Streptococcus pyogenes
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A library of 175 dipeptidomimetics and tripeptidomimetics containing an [alpha]-amino boronic acid or boronate has been synthesized, and the activity toward Mycobacterium tuberculosis, Candida albicans, Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli and Pseudomonas aeruginosa has been screened. Although there is no clear structure-activity relationship, several compounds exhibit promising activity against different pathogens. Copyright © 2013 European Peptide Society and John Wiley & Sons, Ltd. [PUBLICATION ABSTRACT]
ISSN:1075-2617
1099-1387
DOI:10.1002/psc.2583