S-nitrosoglutathione-induced toxicity in Drosophila melanogaster: Delayed pupation and induced mild oxidative/nitrosative stress in eclosed flies

The toxicity of the nitric oxide donor S-nitrosoglutathione (GSNO) was tested on the Drosophila melanogaster model system. Fly larvae were raised on food supplemented with GSNO at concentrations of 1.0, 1.5 or 4.0mM. Food supplementation with GSNO caused a developmental delay in the flies. Biochemic...

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Veröffentlicht in:	Comparative biochemistry and physiology. Part A, Molecular & integrative physiology Molecular & integrative physiology, 2013-01, Vol.164 (1), p.162-170
Hauptverfasser:	Lozinsky, Oleksandr V., Lushchak, Oleh V., Kryshchuk, Natalia I., Shchypanska, Natalia Y., Riabkina, Anna H., Skarbek, Stanislava V., Maksymiv, Ivan V., Storey, Janet M., Storey, Kenneth B., Lushchak, Volodymyr I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aconitase Aconitate hydratase Aconitate Hydratase - metabolism adults Animals antioxidant activity Antioxidant enzymes Biomarkers - metabolism catalase Catalase - metabolism Culture Media - metabolism Development dietary supplements Drosophila melanogaster Drosophila melanogaster - drug effects Drosophila melanogaster - enzymology Drosophila melanogaster - growth & development Drosophila Proteins - metabolism Enzyme Activation Feeding Behavior - drug effects Female glucose-6-phosphate 1-dehydrogenase glutathione transferase Glutathione Transferase - metabolism insect larvae isocitrate dehydrogenase Isocitrate Dehydrogenase - metabolism Larva - drug effects Larva - enzymology Larva - metabolism Male males nitric oxide Nitrites - metabolism Oxidative Stress Oxidative/nitrosative stress Protein Carbonylation protein content Pupa - drug effects Pupa - enzymology Pupa - metabolism pupation Reactive nitrogen species Reactive oxygen species Reactive Oxygen Species - metabolism S-nitrosoglutathione S-Nitrosoglutathione - administration & dosage S-Nitrosoglutathione - toxicity superoxide dismutase Time Factors toxicity
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