Enhanced Induction by X-irradiation of DNA Double-strand Breakage in Mitotic as Compared with S-phase V79 Cells

Summary A marked enhancement of X-ray-induced DNA double-strand breakage was demonstrated for mitotic Chinese hamster (V79) cells compared with S-phase cells or asynchronous cultures, which can explain the high radiosensitivity of mitotic cells. However, mitotic cells required twice the level of DNA...

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Veröffentlicht in:	International journal of radiation biology 1986, Vol.49 (6), p.909-914
Hauptverfasser:	Radford, Ian R., Broadhurst, Sam
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Cell Survival - radiation effects Cricetinae Cricetulus DNA - radiation effects Dose-Response Relationship, Radiation Interphase - radiation effects Mitosis - radiation effects Radiation Tolerance
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Zusammenfassung:	Summary A marked enhancement of X-ray-induced DNA double-strand breakage was demonstrated for mitotic Chinese hamster (V79) cells compared with S-phase cells or asynchronous cultures, which can explain the high radiosensitivity of mitotic cells. However, mitotic cells required twice the level of DNA double-strand breakage to produce a lethal lesion of that required for S-phase or asynchronous cells, suggesting that repair in mitotic cells is less error prone.
ISSN:	0955-3002 0020-7616 1362-3095
DOI:	10.1080/09553008514553141