Prevention of the TPA-mediated down-regulation of protein kinase C

Protein kinase C activity in lymphocytes was down-regulated upon exposure of the cells to 12-0-tetradecanoylphorbol-13 acetate. This down-regulation was prevented by preincubating the cells with sphingosine, a reported protein kinase C inhibitor. Two other protein kinase C inhibitors, palmitoylcarni...

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Veröffentlicht in:	Biochemical and biophysical research communications 1988-02, Vol.151 (1), p.94-99
Hauptverfasser:	Grove, Deborah S., Mastro, Andrea M.
Format:	Artikel
Sprache:	eng
Schlagworte:	12-O-tetradecanoylphorbol-13 acetate Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Cattle Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology lymphocytes Lymphocytes - drug effects Lymphocytes - enzymology Palmitoylcarnitine - pharmacology Phloretin - pharmacology prevention protein kinase C Protein Kinase C - antagonists & inhibitors Protein Kinase C - metabolism Sphingosine - pharmacology Tetradecanoylphorbol Acetate - pharmacology Transferases
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Zusammenfassung:	Protein kinase C activity in lymphocytes was down-regulated upon exposure of the cells to 12-0-tetradecanoylphorbol-13 acetate. This down-regulation was prevented by preincubating the cells with sphingosine, a reported protein kinase C inhibitor. Two other protein kinase C inhibitors, palmitoylcarnitine and phloretin, were ineffective in preventing down-regulation by the phorbol ester.
ISSN:	0006-291X 1090-2104
DOI:	10.1016/0006-291X(88)90563-3