Serum levels of chromogranin A are not predictive of high-grade, poorly differentiated prostate cancer: Results from an Italian biopsy cohort

Abstract Objectives To explore the association of chromogranin A (CgA) levels and the risk of poorly differentiated prostate cancer (CaP) in men undergoing prostate biopsy. Materials and methods Between 2006 and 2012, we prospectively enrolled 1,018 men with no history of CaP undergoing prostate bio...

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Veröffentlicht in:	Urologic oncology 2014-02, Vol.32 (2), p.80-84
Hauptverfasser:	De Nunzio, Cosimo, M.D., Ph.D, Albisinni, Simone, M.D, Presicce, Fabrizio, M.D, Lombardo, Riccardo, M.D, Cancrini, Fabiana, Tubaro, Andrea, M.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Aged Biomarkers, Tumor - blood Biopsy Chromogranin A Chromogranin A - blood Cohort Studies High-grade Humans Italy Logistic Models Male Middle Aged Multivariate Analysis Neoplasm Grading Neuroendocrine Predictive Value of Tests Prognosis Prostate - pathology Prostate cancer Prostate-Specific Antigen - blood Prostatic Neoplasms - blood Prostatic Neoplasms - diagnosis Prostatic Neoplasms - pathology Risk Factors Sensitivity and Specificity Urology
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Zusammenfassung:	Abstract Objectives To explore the association of chromogranin A (CgA) levels and the risk of poorly differentiated prostate cancer (CaP) in men undergoing prostate biopsy. Materials and methods Between 2006 and 2012, we prospectively enrolled 1,018 men with no history of CaP undergoing prostate biopsy. The risk of detecting poorly differentiated CaP as a function of CgA concentration was evaluated using crude and adjusted logistic regressions. Further analyses were performed to determine whether CgA was a significant predictor of high-grade CaP in men with low PSA (
ISSN:	1078-1439 1873-2496
DOI:	10.1016/j.urolonc.2012.07.012