Utility of nicorandil for the measurement of coronary fractional flow reserve

Nicorandil, an adenosine triphosphate (ATP)-sensitive potassium channel opener, has been used as an anti-angina drug that causes coronary vasodilation of both epicardial and resistance vessels. We assessed the hyperaemic efficacy of nicorandil for the measurement of coronary fractional flow reserve...

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Veröffentlicht in:Cardiovascular intervention and therapeutics 2014-01, Vol.29 (1), p.24-30
Hauptverfasser: Oi, Maki, Toyofuku, Mamoru, Matsumura, Yukiko, Motohashi, Yasuyo, Takahashi, Kousuke, Kawase, Yuichi, Ko, Euihong, Tanaka, Mariko, Kitada, Masahiko, Yuzuki, Yosuke, Tamura, Takashi, Tanaka, Nobuhiro, Kimura, Takeshi
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Sprache:eng
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Zusammenfassung:Nicorandil, an adenosine triphosphate (ATP)-sensitive potassium channel opener, has been used as an anti-angina drug that causes coronary vasodilation of both epicardial and resistance vessels. We assessed the hyperaemic efficacy of nicorandil for the measurement of coronary fractional flow reserve (FFR). In this prospective, single-centre study, we enrolled 20 consecutive patients (20 lesions) with intermediate coronary artery stenosis. Hyperaemic efficacy of intracoronary bolus injection of nicorandil (2 mg) was compared with that of continuous intravenous infusion of adenosine triphosphate (ATP, 150 μg/kg/min). The intra-patient difference of FFR value between the two hyperaemic stimuli was evaluated using a non-inferiority design with the margin of 0.03. Among study patients, no serious event occurred with administration of either stimulus. A strong and linear correlation of FFR with ATP and nicorandil was observed ( r 2  = 0.98, P  
ISSN:1868-4300
1868-4297
DOI:10.1007/s12928-013-0207-7