Synthesis of deuterated and tritiated gossypol

Synthesis of deuterated and tritiated gossypol

We report here the synthesis of deuterated and tritiated gossypol by exchange with labelleled water using trifluoroacetic acid as the catalyst. In the case of D2O in tetrahydrofuran, the exchange is complete in 45 minutes at 75°C as determined by a 1H‐NMR spectrum.

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Veröffentlicht in:Journal of labelled compounds & radiopharmaceuticals 1987-06, Vol.24 (6), p.741-743
Hauptverfasser: Stipanovic, Robert D., Williams, Howard J., Muehleisen, David P., Plapp Jr, F. W.
Format: Artikel
Sprache:eng
Schlagworte:
acid catalyzed exchange
deuterium
Gossypol
tritium
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Beschreibung
Zusammenfassung:We report here the synthesis of deuterated and tritiated gossypol by exchange with labelleled water using trifluoroacetic acid as the catalyst. In the case of D2O in tetrahydrofuran, the exchange is complete in 45 minutes at 75°C as determined by a 1H‐NMR spectrum.
ISSN:0362-4803
1099-1344
DOI:10.1002/jlcr.2580240616